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The mammalian liver regenerates upon tissue loss, which induces quiescent hepatocytes case study enter the cell cycle and undergo limited replication under the management of varied hormones, increase factors, and cytokines. Endocannabinoids acting via cannabinoid type 1 receptors CB1R advertise neural progenitor cell proliferation, and within the liver they promote lipogenesis. These findings imply the involvement of CB1R within the management of liver regeneration. In the latest study, researchers document that mice missing CB1R globally or in hepatocytes only and wild type mice handled with a CB1R antagonist have a behind schedule proliferative reaction case study two thirds partial hepatectomy PHX. In wild type mice, PHX leads case study elevated hepatic expression of CB1R and hyperactivation of the biosynthesis of the endocannabinoid anandamide in the liver via an in vivo pathway involving conjugation of arachidonic acid and ethanolamine by fatty acid amide hydrolase. In wild type but not CB1R / mice, PHX induces physically powerful up law of key cell cycle proteins involved in mitotic progression, adding cyclin based kinase 1 Cdk1, cyclin B2, and their transcriptional regulator forkhead box protein M1 FoxM1, as found out by ultrahigh throughput RNA sequencing and pathway analysis and confirmed by real time PCR and Western blot analyses. Treatment of untamed type mice with anandamide induces identical adjustments mediated via activation of the PI3K/Akt pathway. We conclude that activation of hepatic CB1R by newly synthesized anandamide promotes liver regeneration by controlling the expression of cell cycle regulators that drive M phase progression. Mukhopadhyay B, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;10815:6323 8.
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